Glycosylated Haemoglobin as a Risk Predictor of Coronary Artery Disease in Patients with Stable Angina
Published: September 1, 2018 | DOI: https://doi.org/10.7860/JCDR/2018/35654.11985
Deepak Uppunda, Ranjan K Shetty, Pragna Rao, Abdul Razak, Kiran Shetty, Prasad Narayan Shetty, Ravishanker, Ajit Singh
1. PhD Scholar, Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
2. Professor, Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
3. Professor and Dean, Department of Biochemistry, Manipal Academy of Higher Education, Manipal, Karnataka, India.
4. Assistant Professor, Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
5. PhD Scholar, Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
6. PhD Scholar, Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
7. Lecturer, Department of Statistics, Manipal Academy of Higher Education, Manipal, Karnataka, India.
8. PhD Scholar, Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Mani
Correspondence
Dr. Ranjan K Shetty,
Professor, Department of Cardiology, Kasturba Medical College and Hospital, Manipal Academy of Higher Education,
Manipal-576104, Karnataka, India.
E-mail: deepakuppunda18@gmail.com
Introduction: Glycosylated HaemoglobinA1c (HbA1c) is a time-integrated marker for glycaemic control. It also helps in predicting the risk of Coronary Artery Disease (CAD) among diabetic patients.
Aim: To determine the association between HbA1c and severity of CAD in patients with stable angina.
Materials and Methods: A total of 144 patients with the positive cardiac stress test and stable angina who are undergoing a Coronary Angiogram (CAG) were enrolled. The patients were classified into three groups according to baseline HbA1c level (Normal group <5.6%, n=53; pre diabetic group 5.7-6.4%, n=62; diabetic group >6.4%, n=29). One-way ANOVA test analysed baseline characteristics of the study population. The association between HbA1c level and the risk of CADs was calculated by Pearson correlation. A p-value less than 0.05 considered to be significant.
Results: The subjects who were pre diabetic have 1.77 times more odds of having CAD than the patients who are normal OR (95% CI)=1.77 (0.84,3.73). Patients who have diabetes have 3.13 times more odds of having CAD than the patients who are normal OR (95% CI)=3.13 (1.20,8.16), p=0.02. Higher HbA1c levels were associated with higher incidence of CAD.
Conclusion: The study concluded that there was a significant association between raised baseline HbA1c levels and occurrence of CAD in patients with positive cardiac stress test/stable angina.
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